منابع مشابه
Ribonuclease P.
The gene coding for the RNA subunit of ribonuclease P (RNase P) is essential in all free-living organisms. The RNA subunit, itself, is an enzyme and, from its evolutionary tree, we can infer that it is a very ancient molecule. The specificity of this enzyme is that it cleaves other RNA molecules at the junction of single-stranded and the 5' end of double-stranded regions of RNA. One can specula...
متن کاملThe Ribonuclease P Database
Ribonuclease P is the endoribonuclease responsible for the removal of leader sequences from tRNA precursors. Ribonuclease P is a ribonucleoprotein, and in bacteria the RNA alone is capable of pre-tRNA processing in vitro, i.e. it is a catalytic RNA. The Ribonuclease P Database is a compilation of ribonuclease P sequences, sequence alignments, secondary structures, three-dimensional models and a...
متن کاملArchaeal Ribonuclease P Has Multiple Protein Subunits Homologous to Eukaryotic Nuclear Ribonuclease P Subunits
HALL, THOMAS A. Archaeal Ribonuclease P has Multiple Protein Subunits Homologous to Eukaryotic Nuclear Ribonuclease P Subunits (Under the direction of James W. Brown.) RNase P removes the 5 ́ leader from all transfer RNA precursors, and is thus a required factor for protein synthesis. RNase P consists of a catalytic RNA molecule and associated protein, the amount of which varies among phylogenet...
متن کاملRibonuclease P processes polycistronic tRNA transcripts in Escherichia coli independent of ribonuclease E
The first step in the current model for the processing and maturation of mono- and polycistronic tRNA precursors in Escherichia coli involves initial cleavages by RNase E 1-3 nt downstream of each chromosomally encoded CCA determinant. Subsequently, each mature 5' terminus is generated by single RNase P cleavage, while the 3' terminus undergoes exonucleolytic processing by a combination of 3' -...
متن کاملOrigin of Ribonuclease P RNA ( M 1 RNA )
The origin of RNase P RNA is yet an unsolved problem, although one of us (K.O.) formerly pointed out some sequence similarity between RNase P RNA and virusoids (Ohnishi, 1992). Eigen hypothesized that tRNA is the rst gene from theoretical standpoint. On the other hand, we have postulated polytRNA theory (Ohnishi; Endocytobiology V, 407: 1993; Ann. N.Y. Acad. Sci. 707: 524, 1993; Ohnishi et al.;...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.28.16559